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Hormone Treatments for Weight Loss?

>> Monday, April 28, 2014

In our toolbox of obesity treatments, there is very little available as far as medications go.  We know that there are many hormones involved in the the sensation of feeling full (called 'satiety'), so current research is now exploring these hormones, to see if they can ultimately be developed into obesity treatments.

My colleagues and I at the University of Copenhagen have just published one such study in the American Journal of Physiology.  We studied two hormones, GLP-1 and PYY3-36, both of which are hormones that are released when we eat, working to slow down our stomachs and tell our brains that we feel full.  We looked at intravenous infusions of these hormones, to try to understand how they may work together, and how they may affect a person's desire to eat when given in combination.

We found that when GLP-1 and PYY3-36 were given together, the inhibitory effect on food intake was synergistic - ie, more than then sum of each hormone individually.  We found that these hormones together elicited a decrease in a hunger hormone called ghrelin, as well as a slight increase in nausea (due to the stomach slowing effect), but in further analyses, we found that neither of these factors was responsible for the lower amount of food that participants elected to eat after the infusions were complete.

So, this study shows us that these two hormones in combination work together in some way to give us a sense of satiety or fullness, but exactly how they work together is not clear.  One small step forward in the big picture of understanding the complex web of hunger and fullness!

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I am excited that you have arrived at my site, and I hope you are too - consider this the first step towards a Healthier New You!! As a medical doctor, Endocrinologist, and obesity specialist, I am absolutely passionate about helping people with weight management. Though there is certainly no magic cure for obesity, there IS a successful treatment plan out there for you - it is all about understanding the elements that contribute to your personal weight struggle, and then finding the treatment plan that suits your needs and your lifestyle. The way to finding your personal solution is to learn as much as you can about obesity: how our toxic environment has shaped us into an overweight society; the diversity of contributors to obesity; and what the treatment options out there are really all about. Knowledge Is Power!!

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